Clinical Trials

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At KaRa MINDS, we collaborate with international, national and local partners to prevent and treat neurological conditions such as Alzheimer's disease through research.


TrailBlazer Study – Recruiting now

Assessment, tolerability and efficacy of Donanemab in early symptomatic Alzheimer’s Disease, 76 week duration. A Phase 3 Study, 1 ½ year study.

ATHIRA ACT Study - Recruitment open

A Randomized, Phase 2, Placebo-Controlled, Translational Study of ATH-107 in Subjects with Mild to Moderate Alzheimer's Disease.

For further information on this study, please click here.

INVOKE Study - Recruitment open

A Randomized, Phase 2, Placebo-Controlled, multicentre study to evaluate the efficacy and safety of AL002 in early Alzheimer’s disease. 

ANAVEX AD Study - Recruitment closed

A Phase 2b/3, Double-Blind, Randomized, Placebo-Controlled 48-week Safety and Efficacy trial of ANAVEX2-73 for the Treatment of Early Alzheimer’s disease. 

XPRO Study - Recruiting

Phase 1b Open-Label, Dose-Identification Study of XPro1595 in Patients with Mild to Moderate Alzheimer’s Disease with Elevated high sensitivity C-reactive protein in Blood.

For further information on this study, please click here.

3D Study – Recruitment open

A Phase 2, Double-Blind, Randomized, Placebo-Controlled 52-week clinical proof of concept study for the treatment of Deferiprone to Delay Dementia.

Clarity Study – Recruitment closed

A Phase 3, Placebo-Controlled, Double-Blind, Parallel-Group, 18-Month Study with an Open-Label Extension Phase to Confirm Safety and Efficacy of BAN2401 in Subjects with Early Alzheimer’s Disease.

For further information on this study, please click here.

EMBARK – Prior Engage study participants only

Phase 3b open-label, multicentre, safety study of BIIB037 (aducanumab) in subjects with Alzheimer’s disease who had previously participated in the Aducanumab studies.

KARVIAH_XTND Study - Open to previous participants

Longitudinal investigational study examining blood, brain and lifestyle risk factors in an older at risk of AD population.

Retinal Study - Adjunct study only

Investigating the diagnostic utility of hyperspectral retinal imaging in preclinical Alzheimer’s disease.


ANAVEX Parkinson's disease dementia – Recruitment closed

A Phase 2, Double-blind, randomised, placebo-controlled study to evaluate the safety, tolerability and efficacy of ANAVEX2-73 for cognitive impairment in patients with Parkinson’s Disease with dementia.

Mission AD Study

A Placebo-Controlled, Double-Blind, Parallel-Group, 24 Month Study to Evaluate the Efficacy and Safety of E2609 in Subjects with Early Alzheimer's Disease.

XanADu Study 

A Phase II, Double -Blind, 12-Week, Randomised, Placebo-Controlled Study to Assess the Safety, Tolerability and Efficacy of XanamemTM  in Subjects with Mild Dementia due to Alzheimer’s disease.


Biomarker qualification for risk of mild cognitive impairment due to Alzheimer’s disease and safety and efficacy evaluation of Pioglitazone in delaying its onset (TOMORROW).


A Phase 2b/3 randomised, double-blind, placebo-controlled, parallel Group, Multicenter Study Investigating the Efficacy and Safety of JNJ-54861911 in subjects who are Asymptomatic and at risk for developing Alzheimer's disease.


A Phase 3 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Aducanumab (BIIB037) in Subjects with early Alzheimer’s disease.


A multinational, multi-center, randomized, double-blind, active comparator, phase III clinical trial to evaluate the efficacy and safety of donepezil transdermal patch in patients with Alzheimer’s disease.


Investigation of curcumin for the prevention of Alzheimer’s disease in cognitively healthy individuals, examining the blood, brain and retina.

TotAL Study - Recruitment via Macquarie University (Cognitively Healthy Males)

A 56 week, Double-Blind, Randomised Study to Evaluate the Efficacy of Testosterone, With and Without DHA Supplementation on Cerebral Amyloid Load in Known Brain Amyloid-PET Positive Men with Subjective Memory Complaints.

XPRO Study

An open label, 12-week study to investigate the efficacy and safety of XPRO 1595 in Subjects with early-mod Alzheimer's disease.


For further details on any study, please call KaRa MINDS or use the Contact Us form at the bottom of the page and our friendly team will be in touch.